Research progress of chiral ligand exchange stationary phases in the enantiomer resolution

The structure of chiral drugs contains at least one asymmetric center. When the enantiomers act on human body, they are recognized by receptors and enzymes in vivo, which will show different physiological effects even adverse reactions. Therefore, it is very important for development pharmacy to obtain with a single configuration racemic resolution. Some general impurities be introduced production drugs, thus detection also crucial step quality control medicines. ligand exchange stationary phase has strong recognition effect enantiomer analytes multiple chelating sites, suitable separation biological samples such as amino acids. In this work, phases enantiomeric resolution reviewed, expected provide basis complex drug components.